308 Elevated p53 expression was observed in heart samples from patients with dilated cardiomyopathy
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The usual mechanistic explanation is that the GHRH arm drives somatotroph cAMP signalling while the GHRP arm additionally attenuates somatostatin tone, so the two are acting on different limbs of the same axis rather than competing for one receptor
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The Hidden Cardiac Risk: hERG Channel Blockade Both drugs unintentionally blocked the hERG (human Ether--go-go-Related Gene) potassium channel, responsible for the rapid delayed rectifier potassium current (IKr) in cardiac myocytes