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There is currently no FDA-approved indication for tirzepatide in treating substance use disorders, and clinicians should recognize that any discussion of addiction-related benefits remains investigational

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As the first anti-obesity drug targeting multiple receptors, tirzepatide (Zepbound, Eli Lilly), a dual GIPR/GLP-1R agonist, was approved by the FDA in 2022

[1] [3] Discuss effective contraception with your clinician if relevant