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Ablation of either of these branches increases hepatic lipogenic gene expression and steatosis while leading to unresolved ER stress, characterized by sustained UPR activation and, in particular, elevated ATF4/CHOP signaling
The overlap in observable outputs does not imply mechanistic overlap
An improvement in cardiometabolic health by reducing cholesterol levels, which can increase with a decline in estrogen
doi: 10.1161/CIRCRESAHA.121.319181 140
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