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Ephelides (plural of ephelis) are usually found in fair-skinned individuals, are due to sunlight exposure, occur in childhood, tend to diminish with age, and are lighter in appearance
As previously discussed, bacterial products, collectively known as PAMPs and MAMPs, derived from the gut, reach the liver via portal circulation and systemic circulation through the mesenteric lymph nodes, and may induce an inflammatory response by activating Toll-like receptors (TLRs)
[55] Medication-based treatment may be preferred when patients decline surgery, have lower surgical risk thresholds, require reversible treatment, or need cardiometabolic risk reduction without anatomic intervention
10.1152/ajpgi.00064.2011 14 ChaboryE.DamonC.LenoirA.KauselmannG.KernH.ZevnikB.et al (2009)
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