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Lack of clinical evidence and human trial data While the mechanisms of action of Schisandra chinensis and its lignans are well-documented, the majority of research is preclinical, with only a few human studies available [121,122,123,124]
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Preclinical studies have demonstrated that PEG-MGF promotes myoblast proliferation, delays satellite cell differentiation, and increases the number of proliferating muscle precursor cells available for fiber repair a mechanistically distinct profile from IGF-1 LR3 or DES(1-3) IGF-1, which more directly stimulate protein synthesis in committed myotubes
Contrary, NP4 showed a cytotoxic effect in the very low micromolar range (143B: IC 50 = 6.6 M, K7M2: IC 50 = 2.1 M) (drug-response curves: Fig
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