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doi:10.1007/s40279-019-01243-1 Govindasamy, Karuppasamy et al

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It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate

Most studies involve limited sample sizes, short duration, or lack comprehensive safety evaluations