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Patients unable to tolerate gastrointestinal side effects: While most patients adjust, some cannot tolerate the nausea and other GI effects

Significantly, it has been demonstrated that GLP-1 analogues can suppress NF-B, which is a major activator of IL-6 expression [121]

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This approach allowed us to capture a wide range of studies, from early foundational work to recent clinical trials, providing a balanced overview of the field