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What about quality and safety - embedded in a licensed product
We excluded patients with cirrhotic liver, history of gall bladder, biliary disorders, pancreatic diseases, interrupted use of GLP-1RAs throughout the study period, and patients used other drugs with potential effects on the motility of biliary tracts such as cholecystokinin, motilin hormone, cholinomimetic agents like prostigmine, erythromycin, cisapride, cholystyramine, intravenous aminoacids, cholinergic agents like atropine, somatostatin, and progesterone, trimebutine, loperamide and ondansetron
Li J, Woodward M, Perkovic V et al (2020) Mediators of the effects of canagliflozin on heart failure in patients with type 2 diabetes
Microdosing uses doses and schedules that differ from FDA-approved labeling and is considered an off-label approach
doi:10.1017/S095442241700018X
A supportive care model such as Mochis helps patients adjust doses safely rather than pushing through discomfort that may not be necessary
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