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IH causes mitochondrial damage, resulting in the production of mitochondrial reactive oxygen species (mtROS) and oxidized mitochondrial DNA (mtDNA), both of which activate the inflammasome (Zhou et al., In addition to mitophagy, manganese superoxide dismutase (SOD2) is a mitochondrial antioxidant enzyme that provides another source of protection against mtROS (Flynn and Melov, Overall, IH is a major contributor to inflammasome activation in immune cells
It's important to note that 'food noise' is not a formal medical diagnosis in UK clinical guidance, but rather a patient-described concept that has gained recognition as a meaningful description of the cognitive burden some people experience with disordered eating patterns and obesity
One study found that vitamin C plays an important role in restoring depleted glutathione levels (4)
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Young, 2002)
