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A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

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As far as dosage for bodybuilding is concerned, research suggests 75 mcg/day for beginners, 100 mcg/day for intermediates, and 150 mcg/day for advanced users