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Complete symptom resolution typically requires several weeks to months of regular treatment

The abundances of different cell types varied among samples were observed

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Abbreviations R/R DLBCL: Relapsed/Refractory Diffuse Large B-Cell Lymphoma R-CHOP: Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone ICIs: Immune Checkpoint Inhibitors PD-1: Programmed Cell Death Protein 1 PD-L1: Programmed Death-Ligand 1 ROS: Reactive Oxygen Species ER: Endoplasmic Reticulum ICD: Immunogenic Cell Death DAMPs: Damage-Associated Molecular Patterns CRT: Calreticulin HMGB1: High Mobility Group Box 1 ATP: Adenosine Triphosphate DCs: Dendritic Cells GSTs: Glutathione S-Transferases NBDHEX: 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol NAC: N-acetylcysteine MMP: Mitochondrial Membrane Potential WB: Western Blot IHC: Immunohistochemistry H&E: Hematoxylin and Eosin RNA-seq: RNA Sequencing BMDCs: Bone Marrow-Derived Dendritic Cells GzmB: Granzyme B IFN-: Interferon Gamma 4-PBA: 4-Phenylbutyric Acid References Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, et al

So, it is also no surprise that one of the largest glutathione stores in the body is located in the liver