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Expert Rev Clin Immunol 2016
Starting at 5 mg instead of 2.5 mg Some providers start patients at 5 mg when: The patient was on maximum-dose semaglutide (2.0 to 2.4 mg) for 6 or more months with good tolerance The patient experienced no significant GI side effects on semaglutide Weight loss has been stalled for 8 or more weeks despite medication compliance The patient has a BMI above 40 and more aggressive weight loss is clinically appropriate A study examining GLP-1 to tirzepatide transitions found that patients who started at 5 mg had manageable side effects and comparable outcomes to those who started at 2.5 mg, provided they had prior GLP-1 experience
A mix of cardio and low-intensity movement (like walking) is valuable
A GSSG standard is provided to generate a standard curve for the assay and all samples should be read off the standard curve
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Over-the-counter anti-diarrheal medications such as loperamide (Imodium) or bismuth subsalicylate (Pepto-Bismol) can provide symptomatic relief during the adjustment period
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