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43 percent of participants achieved a 5 percent or greater reduction in body weight (compared to 19 percent on placebo)

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Why the benefits of GLP-1 medications outweigh the risks GLP-1 drugs like Ozempic and Mounjaro offer life-changing health outcomes: 1020% weight loss Better control of type 2 diabetes Lower blood pressure and cholesterol Reduced risk of heart disease, stroke, and kidney damage For most patients, these benefits outweigh the very low and uncertain risk of pancreatitis

To reduce the observed selection bias between the 2 groups, inverse probability of treatment weighting (IPTW) [15] using average treatment effect weights was derived by conducting a logistic regression with the following variables: age, sex, race/ethnicity, geographic region, index year, Charlson Comorbidity Index, diabetes complications severity index, type of ASCVD history, comorbidities, glucose-lowering therapy, HbA1c, body mass index (BMI), and number of all-cause hospitalizations 60 days prior to the index date

In some situations, bariatric surgery may be considered for patients meeting specific criteria, particularly those with BMI 40 kg/m or 35 kg/m with obesity-related complications, as outlined in NICE guidance

Large-scale genome-wide analysis links lactic acid bacteria from food with the gut microbiome