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For instance, AARS1-mediated lactylation of p53 at lysines 120 and 139 suppresses the transcription of p21, and p53 upregulates modulator of apoptosis (PUMA) by disrupting p53 LLPS and its DNA-binding capability

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(B) LRs from dHL60 cells were extracted with MNE buffer containing 1% triton X-100 and applied to discontinuous sucrose gradients, as described in Methods

It does not require conversion by the body, making it easier to utiliseespecially for those with impaired methylation pathways

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