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"While it is disappointing that the trials did not meet their primary endpoints, they show a fundamental shift in how we approach the development of new Alzheimer's treatments, expanding beyond amyloid to target the complete pathobiology of the disease," said Howard Fillit, MD, Co-Founder and Chief Science Officer of the Alzheimer's Drug Discovery Foundation (ADDF)

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More than one billion people worldwide live with obesity, which increases risk for Type 2 diabetes, high blood pressure, heart disease, stroke, metabolic syndrome, fatty liver diseases, some cancers, kidney disease, breathing problems, and sleep apnea

Participants also lost an average of 1820% of body weight over 52 weeks