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SUSTAIN-2, SUSTAIN-3, and SUSTAIN-4 all enrolled patients already on metformin and showed mean A1C reductions of about 1.5 to 1.8% with semaglutide 1.0 mg on top

Immunologic And Local Reactions: Injection Site And Allergic Reactions Local reactions such as redness, itching, and mild swelling at the injection site occur commonly and resolve within days

2025;120(10S2):S885

As an indispensable member of anti-tumor immunity, CD4 + T cells promote anti-tumor immunity by assisting CD8 effector T cells or directly eliminate tumor cells by acting as cytotoxic T cells (Oh and Fong, 2021)