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Animal studies identified an increased risk of thyroid C-cell tumours with GLP-1 receptor agonists, though there is no confirmed link in humans

Caveolin-1 (Cav-1) is expressed less while induced by HIF-1, which regulates E-cadherin to cause the epithelial-mesenchymal transition (EMT) in gastric cancer (80)

Brand-name GLP-1 medications can be expensive when paid out of pocket

Since GSTO1 knockdown has been known to result in increased protein glutathionylation 14 , glutathione depletion by CHAC1 could possibly contribute in restoring the glutathionylation balance

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