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[42] demonstrated in healthy volunteers that infusion of native GLP-1 during breakfast increased satiety and fullness and reduced the caloric intake in the next meal by 12%
In contrast, Wegovy is a higher-dose form of injectable semaglutide marketed separately for chronic weight management in people with obesity
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Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class
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However, avoid mega-dose vitamin A supplements, which can build up in your liver during prolonged therapy
