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Due to its extremely poor elimination rate, cadmium accumulates in soft tissues- primarily liver and kidneys via systemic circulation and classified as one of the most hazardous metals to human health inducing hepatic, renal and neurological injury 2

The absolute bioavailability (F) of an oral formulation, for example, is calculated using the following dose-normalized equation: Factors Affecting Bioavailability Drug Properties: The intrinsic physicochemical properties of the drug are especially important

pennellii (Lpa) (Mittova et al., 2000)