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197 Furthermore, microarray data from rheumatoid arthritis (RA) patients have shown a significant increase in the expression of ZIP8 in peripheral monocytes compared to healthy controls

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In vitro , a collagen-derived dipeptide, prolyl-hydroxyproline (Pro-Hyp), has been shown to reduce adipocyte size and increase the expression of beige-fat-specific genes, including C/EBP, PGC-1 and uncoupling protein 1 (UCP1)