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The idea of simultaneously activating both the GIP and GLP-1 receptors seems appealing for treatment of T2DM since it may significantly boost insulin secretion and improve insulin sensitivity

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Appetite and Satiety Effects The theoretical appeal of combining these two is additive appetite suppression

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In the same Diabetes, Obesity and Metabolism meta-analysis, CagriSema led to a 7.5% greater weight loss (roughly 17 pounds more) than semaglutide alone