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No tolerance development has been documented, suggesting ongoing benefits with consistent use
Take 1 or 4 film once a day
CBX3 represses CUL3 transcription, leading to reduced NRF2 ubiquitination and degradation
Instead of forcing a response, it appears to remove bottlenecks and enhance processes that are already trying to happen
Therefore, studying the mechanisms of drug resistance is important in parallel with the development of the drug itself
Cell 8 , 353364 (2005)
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