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Overall, these findings are complementary to results in a companion article 57 , in which the body-weight-reducing and food-intake-reducing effects of GIPR antagonism are disrupted in mice with global loss of either Gipr or Glp1r but preserved in mice with loss of Gipr in either GABAergic or peripheral neurons
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Kuhre RE, Ghiasi SM, Adriaenssens AE, et al
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The findings demonstrated that Semaglutide produces clinically meaningful and sustained weight loss, and most importantly, provides cardiovascular benefits irrespective of the amount of weight lost, highlighting its broad impact on metabolic health
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