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Additionally, those with low B12 levels may be at an increased risk of developing dementia or other neurological conditions
NAD+ & cellular metabolism Explored in cell research on how NNMT inhibition affects NAD+ and SAM levels investigational, animal and in-vitro only
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[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe
