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The biologic effects of growth factor-toxin conjugates in models of vascular injury depend on dose, mode of delivery, and animal species
Plasma/serum vs
For drugs that are given by continuous IV infusion, the equation for calculating C ss is where R o = the infusion rate CL = clearance (mL/min) Note that the time to reach steady-state concentration is solely determined by the half-life
Proc Amer Assoc Cancer Res 47:4977, 2006
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Sever et al., 2019
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