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PTPN22 (short for protein tyrosine phosphatase non-receptor type 22), known as a risk factor in multiple autoimmune disorders, reduces T-cell activity by removing phosphate groups from phosphorylated proteins such as LCK, Fyn, and Zap70, which are associated with T-cell receptor signaling pathway
The short answer: it depends on the peptides
Sulfa allergy is caused by the nitrogen containing heterocyclic ring and aryl-amine moiety
BPC-157 was among them (source)
Effect of Divalent Ions on Stability of Bacillus anthracis InhA Metalloprotease
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