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Access this article Similar content being viewed by others Abbreviations T4: Thyroxine T3: Tri-iodothyronine DIT: Di-iodothyronine MIT: Mono-iodothyronine TSH: Thyrotropin or thyroid stimulating hormone UDPGT: Uridine diphosphate glucuronyltransferase SULT: Sulfotransferase NIS: Sodium-iodide symporter TPO: Thyroperoxidase AOP: Adverse outcome pathway KE: Key events MIE: Molecular initiating event MoA: Mode of action Ph II: Phase 2 metabolism TTR: Transthyretin TBG: Thyroxine binding globulin NIS: Sodium iodide symporter rT3: Reverse T3 T3S: Sulphated T3 TRE: Thyroid response elements PPAR: Peroxisome proliferator activated receptor RXR: Retinoid X receptor CAR: Constitutive androstane receptor IGF: Insulin like growth factor PCB: Polychlorinated biphenyl PBB: Polybrominated biphenyl TCDD: Tetrachlorodibenzo- p- dioxin PTU: 6-Propylthiouracil CSF: Cerebrospinal fluid MCT: Monocarboxylate transporter OATP: Organic anion transporter protein NOAEL: No observable adverse effect level References Abe T, Kakyo M, Sakagami H et al (1998) Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with OATP2

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