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This happened when totally inconsistent results were published by several groups using JNK2-deficient mice [36, 134136] and it was later discovered that the reason for the contradictory data was caused by the mislabeling of the background strain for JNK2 KO mice by the vendor [137], which led to the use of WT and KO mice with mismatched genetic background

However, our study is based upon a relatively small number of control and DS cases and it will be important for this work to be replicated using larger sample sizes

Body weight does not drive dose

When the body effectively removes toxins, skin clarity improves

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It is a fundamental tool for exploring independent or synergistic multi-pathway metabolic interventions