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Although metformin is known as an AMPK activator 15 , it neither induces beta cell apoptosis nor ameliorates MG-induced beta cell apoptosis

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4 Conclusion In conclusion, due to its multifaceted and heterogeneous nature, a personalized approach is necessary for obesity management, especially in syndromic obesity like PWS where the underlying pathophysiology remains largely unknown

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Our study illustrates the importance of studying ciliopathies, not only as rare genetic disorders but also as critical contributors to metabolic dysregulation in more prevalent forms of obesity