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Conclusion COVID-19 is a historic challenge to the fields of research, infectious disease, and global healthcare (Hunter et al., 2022)

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Similarly, as the genetic deficiency of vacuolar protein sorting protein 18 (VPS18) is reported to facilitate the lysosomal degradation of LOX, the impaired dendritogenesis in VPS18 knockout mice was suggested to be correlated with the accumulation of LOX (52)

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The reduction in lipogenic gene expression appears attributable to both weight loss and mechanisms independent of weight loss, since a similar magnitude of weight loss induced by a low-calorie diet elicited a smaller reduction in lipogenic gene expression than FGF21 (101)

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