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Mild digestive upset may occur in sensitive individuals, though this is uncommon with liposomal delivery systems
Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes
Copper accumulation also becomes a theoretical concern at extreme doses, though practical protocols stay well below problematic thresholds
Exclusion criteria included: (i) allergies to milk, rice, or nuts
10.1016/j.athoracsur.2004.10.030 86
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