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Therapeutic Scope and the Translational Mismatch Problem Clinically, GLP-1RAs are established therapies for obesity and type 2 diabetes (T2D), with expanding indications and ongoing investigation across multiple organ systems
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(PubMed) Delaney CL, Spark JI, Thomas J, Wong YT, Chan LT, Miller MD
In this regard, it is interesting that IgG antibodies that show similar FcRn binding properties can have variable plasma half-lives due to differences in biophysical properties, such as pI and net charge, which affect cellular handling 83,84,85,86,87
Inoue M, Hara M, Nagashima F, Matsui S, Mitsuyasu N, Morino Y: Affinity chromatography of hepatic glutathione S-transferases on omega-aminoalkyl sepharose derivatives of glutathione
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