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Biochem Biophys Res Commun 223: 624-632, 1996
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Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage
Endocrinology 152, 405413.CrossRefGoogle ScholarPubMed + -coupled neutral amino acid transporter 2
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1A) using fluorescence-activated cell sorting (FACS) analysis of the the lipid peroxidation sensor dye BODIPY-C11
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