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If you have a mood disorder like depression or anxiety, and you want to take SSRIs, it can be a long journey to find one that is effective with a side effect profile you can handle

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Retrieved June 2025, from Cleveland Clinic

Problems with systemic anti-melasma agents Although most of these systemic agents are devoid of serious adverse effects, probably with the exception of glutathione, their use as a skin-whitening agent for the treatment of melasma is not yet approved by the United States Food and drug administration (USFDA).[] However, their unregulated use by untrained people may lead to several lethal complications such as sepsis, air embolism, transmission of human immunodeficiency virus and Hepatitis B (parenteral formulations)

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