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Moreover, a recent study revealed T-bet and CD39 as two critical fate-determining markers that enable the effective stratification of CD8 + T cells in TdLNs into two distinct subsets, namely, a T-bet + intermediate-exhausted population associated with ICI therapeutic responsiveness and a CD39 + terminally exhausted subset linked to treatment resistance [235]
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Previous studies in obese rodents and diet-induced obesity models have shown that GEs primary site of action is central, particularly within hypothalamic regions such as the supramammillary nucleus, lateral hypothalamus, and the nucleus of the solitary tract (Tiano et al., 2015)
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