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Dietary advice for people on GLP-1 medications typically includes ensuring adequate fiber intake

Sulagna Misra, MD, internal medicine physician, obesity medicine specialist, and founding physician at Misra Wellness, recommends patients take their first dose on a weekend or when they dont have obligations to leave the house

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However, the medication's effects on gastrointestinal motility and common side effects like diarrhea may theoretically make intestinal mucus more visible in some patients

Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]