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Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis

1 GLP-1R is involved in regulating both insulin and glucagon secretion, and its knockout can impair pancreatic function, thereby affecting the balance of these hormones and glucose homeostasis

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in alzheimers disease

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Interestingly, such signs of mitochondrial dysfunction have also been described in MDD and long COVID: de Boer et al

A., Yamamah, G