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Rarely, patients may experience mild diarrhea, itching, or skin rash with high-dose vitamin B12 supplementation
For patients requiring urgent or emergent procedures, proceed and treat the patient as full stomach and manage accordingly
Semaglutide (Rybelsus) , NHS, 2026 [Accessed 25 June 2026]
Common Side Effects Reported Across Phase 2 trials, participants experienced dose-dependent GI symptoms that are characteristic of GLP-1 receptor agonists: Nausea most frequent, especially during dose escalation Vomiting typically mild to moderate, subsiding with continued use Diarrhea and constipation fluctuating depending on individual tolerance Abdominal discomfort transient and often improved over time Dose-Response Relationship At lower doses (14 mg weekly), side effects were generally mild and manageable, though some participants still reported early GI symptoms
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