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In addition to the ASO, the efficacy of an RNAi directed at PNPLA3, known as LY3849891, is also being evaluated in clinical trials for patients with MASH with PNPLA3 variants (NCT05395481) 64
Bedtime dosing takes advantage of the natural nocturnal GH surge and aligns with the bodys circadian hormone rhythm
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In addition, although changes in oxidative stress markers have been reported, direct evidence linking GLP-1RA therapy to constrained redox buffering capacity remains limited
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