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These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities

However, the therapeutic ceiling of GLP-1 monotherapy, along with the heterogeneous nature of obesity, has highlighted the significance of developing more potent agents, engaging multiple nutrient-stimulated hormone (NUSH) pathways [7]

Targeting Notch degradation system provides promise for breast cancer therapeutics

Almost no peptide permeated untreated skin over the same period

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Cardiac CT scans were used to measure total and left atrial epicardial fat volume and density, while echocardiography tracked changes in cardiac structure