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Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising translational tool to target human aging

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26 However, according to a metaanalysis of 6 CoQ10 supplement studies and a careful study of CoQ10 supplementation in subjects with statin-associated myalgia confirmed by a blinded run-in protocol, CoQ10 supplementation has not been shown to reduce statin-associated myalgia