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doi:10.1007/s11325-023-02890-5
Although less common, oral administration can be an alternative for those averse to injections Side effects are generally rare and temporary, and include: To minimize side effects, start with lower doses and gradually increase it
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But how do they work, and how do they compare
Moreover, ALA exerts antioxidant effects via a dual mechanism: (i) rapid redox-cycling between its disulfide (ALA) and dihydrolipoate (DHLA) forms, which directly quenches ROS without transcriptional activation, and (ii) secondary upregulation of the Nrf2 pathway and suppression of NF-B nuclear translocation (Ghibu et al., 2009)
PlexusDx recommends starting at lower doses and titrating upward every 4 weeks to minimize side effects while maximizing metabolic benefit
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