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Investigating Mechanisms in Humans: While preclinical studies have elucidated many molecular pathways, further research is needed to confirm if these mechanisms operate identically or with similar magnitude in human physiology

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This pathway contributes to endothelial function and localized blood flow at sites of tissue injury

To optimize effective absorption, patients are required to adhere to complicated dosing conditions of taking the drug in a fasting state (at least 30 minutes before any food intake) with no more than 4 ounces (approximately 120 mL) of plain water

Front Behav Neurosci 16:987697 Ma Q (2013) Role of NRF2 in oxidative stress and toxicity