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Comparative Biochemistry & Physiology Part A Molecular & Integrative Physiology 170 , 3845 (2014)
Semaglutide cut major cardiovascular events by 20% in people with obesity and existing heart disease but no diabetes, and the benefit showed up early, before most of the weight came off
This creates a perverse incentive situation that merits discussion with your insurance provider before starting any alternating protocol
Furthermore, its significant anti-inflammatory properties have been demonstrated in epilepsy models, where it diminishes seizure severity by inhibiting the NLRP3 inflammasome (Wang et al., 2021), and in multiple sclerosis models, where it reduces demyelination and cognitive impairment (Sadek et al., 2023
How to take it: Its important to take Contrave at the same time every day, but not with a high-fat meal, as this can increase the risk of side effects
Smaller, balanced, lower fat and more bland meals can help to prevent the gastrointestinal discomfort often associated with these medications
