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Furthermore, GE2 reduced inflammation in the amygdala, regardless of diet, but only in males The inflammatory reductions in these areas were found to encompass both TH1 and TH2 produced cytokines

10.1016/j.ejphar.2015.09.024 292

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These agonists are primarily used to manage type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, thereby lowering blood sugar levels

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Guidelines suggest the additional use of DPP-4 inhibitors after metformin failure in patients that do not require antidiabetic therapy with proven cardiovascular benefit