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Over longer treatment periods, this gap may widen further, though extended Retatrutide data awaits Phase 3 completion

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NICE guidance (NG28) for type 2 diabetes management recommends considering SGLT2 inhibitors as the first intensification option for patients with established cardiovascular disease

In the phase 2 obesity and diabetes trials, more participants receiving retatrutide reported nausea compared with those in the placebo group

The researchers found that patients who followed a bland diet, avoided spicy and acidic foods, and took semaglutide with meals were less likely to experience severe GI side effects