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Supplementing with glutathione can significantly increase circulating levels of glutathione in the body

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Precautions: Asthma, Chronic heart failure, Diabetes mellitus, Peripheral vascular disease, Conduction defects or heart block, Depression, Raynaud's disease, Hypotension Special indications: Concurrent hypertension, Angina, Post myocardial infarction, Tremor, Anxiety or panic attacks (specifically propranolol) Taper beta blockers to avoid withdrawal symptoms

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Mitophagy eliminates surplus or malfunctioning mitochondria, regulating the quantity of mitochondria and preserving energy metabolism to preserve mitochondrial homeostasis

Abbreviations CVOTs: Cardiovascular outcome trials DPP-4 inhibitors: Dipeptidyl peptidase-4 inhibitors GLP-1RA: Glucagon-like peptide-1 receptor agonists SGLT-2 inhibitors: Sodium-glucose cotransporter 2 inhibitors MACE: Major cardiovascular events RR: Risk ratio HHF: Hospitalization for heart failure References IDF Diabetes Atlas 2021 10th edition