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According to a 2019 study in The Lancet , acetaminophen toxicity accounts for nearly half of the cases of acute liver failure in North America and about a fifth of the liver transplant cases in the U.S

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Chem Eng J 445:136793 Ueda K, Ishida M, Sakai C, Kobayashi Y, Yoshizumi M, Ishida T (2021) Abstract 10926: importance of mitochondrial DNA damage in cigarette smoke extract-induced activation of innate immune system

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