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In addition, in terms of protein expression, the addition of two selenium sources significantly increased the protein expression of GPX1 and TrxR3

Improved potency and selectivity of Compound 11 toward PDE1B suggest that further substitution, such as difluoro-pyran-methyl-pyridine and methoxybenzyl at the C-6/C-8 and C-9 positions, can be employed to develop more potent PDE1B inhibitors

10.1016/j.mam.2008.05.005 Mol Aspects Med

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