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By slowing digestion, reducing appetite, and helping regulate blood sugar, semaglutide can support substantial improvements in metabolic health

pubmed.ncbi.nlm.nih.gov/15504597/ Shemesh Z, Attias J, Ornan M, et al

Ipamorelin can increase hunger through GHSR activation (ghrelin receptor)

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Recent innovations in adaptive trial designs: A review of design opportunities in translational research

Thus, we chose these numbers for sample size calculations, to discriminate the groups by at least 1 STD in each measure